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MATERNAL SERUM AND TISSUE LEPTIN IN FIRST TRIMESTER SPONTANEOUS MISCARRIAGES | ||
| Duhok Medical Journal | ||
| Article 9, Volume 10, Issue 1, 2016, Pages 9-9 | ||
| Authors | ||
| SARMAD RAHEEM KAREEM1; MEHRI MIRHAJ MUHAMMDSALIH2 | ||
| 1Assistant Professor of Pathology, School of Medicine, Koya University | ||
| 2Assistant lecturer, Koya technical institute | ||
| Abstract | ||
| Background and objectives: Spontaneous miscarriage is a term used for a pregnancy that ends on its own, within the first (20) weeks of gestation, mostly occur during the 1st thirteen weeks of pregnancy. This study investigates the role of maternal serum and tissue leptin expression as a possible endocrine cause for early spontaneous miscarriages. Methods: The study included three groups of women; (34) cases presented with 1st trimester spontaneous miscarriage, (34) cases with normal ongoing 1st trimester pregnancy, and (34) cases of normal non pregnant women with comparable age range regarded as a control group. Serum leptin concentration determined for study groups and trophoblastic immunohistochemical expression of leptin was studied in miscarriage group. Results: Serum leptin concentration in miscarriage group was significantly lower than both pregnant and the non-pregnant (control) women. Also pregnant women show significantly higher leptin concentration as compared to non- pregnant control group and the correlation between maternal serum concentration and trophoblastic immunohistochemical expression of leptin was statistically significant. Conclusion: Low level of maternal leptin hormone concentration in miscarried women and its significant correlation with trophoblastic immunohistochemical expression of leptin indicate the important role of leptin hormone in spontaneous miscarriage and maintaining normal pregnancy. | ||
| Keywords | ||
| Leptin; Miscarriage; Immunohistochemical | ||
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