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DOES OXIDATIVE STRESS INCREASE FOLLOWING IRON THERAPY DURING THE 2ND AND 3RD TRIMESTERS OF PREGNANCY | ||
| Duhok Medical Journal | ||
| Article 12, Volume 10, Issue 1, 2016, Pages 12-12 | ||
| Authors | ||
| RAED SALIM AL-NAEMI1; AHED NAJIM ALDEEN ATRUSHI2 | ||
| 1Professor, Department of Physiology, College of Medicine, University of Duhok | ||
| 2Master Student in Medical Physiology, College of dentistry, University of Duhok | ||
| Abstract | ||
| Background: Pregnancy contributes to the processes of oxidation and free radical formation, the causes may be due to mitochondria rich placenta and a number of transitional metals, especially iron, which is particularly abundant in the mammalian placenta, are important in the production of free radicals. Objective: to evaluate the oxidative stress status at the 3rd trimester of pregnancy in two groups of pregnant women according to the iron supplement therapy. Methods: Enzyme linked immune sorbent assay (ELISA) technique was used for assessing the serum oxidative stress biomarker; malondialdehyde (MDA), total antioxidants capacity , ferritin and complete blood picture were studied in 81 pregnant women at the 3rd trimester of pregnancy who were routinely visited the Duhok maternity hospital for checking up their pregnancy , forty one of them who were took Iron therapy continuously during the 2nd and 3rd trimester of pregnancy and forty women who didn’t took iron at all during their pregnancy. The inclusion criteria were young pregnant women below the age 35 years with their hemoglobin > 11 g% and absence of any chronic medical problem. Results: serum MDA, ferritin, Hb and pack cell volume were significantly higher in pregnant women who took iron than those who didn’t took any iron supplement. Conclusion: higher oxidative stress and lipid peroxidation was found in women at the late stage of the 3rd trimester of pregnancy in iron treated group was shown by increased serum MDA levels due to increase serum ferritin. The higher serum MDA and ferritin during the 3rd trimester of pregnancy in ladies who took iron continuously will probably provide the need of guidance for planning the iron supplement dosage regime. | ||
| Keywords | ||
| iron; Pregnancy; Oxidative stress; Ferritin; Total antioxidants | ||
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