IMPACT OF OXIDATIVE STRESS IN RECURRENT MISSED ABORTION

AL-NAEMI, RAED SALIM; ABDULLAH, QASIM H.; IBRAHIM, SHEREEN. A.

	IMPACT OF OXIDATIVE STRESS IN RECURRENT MISSED ABORTION
Duhok Medical Journal
Article 14, Volume 10, Issue 1, 2016, Pages 14-14
Authors
RAED SALIM AL-NAEMI¹; QASIM H. ABDULLAH²; SHEREEN. A. IBRAHIM³
¹Professor, Department of Physiology, College of Medicine, University of Duhok
²Professor., Department of Physiology, and the Dean, College of Medicine, University of Duhok
³Lecturer, Department, of Physiology, College of Medicine, University of Duhok
Abstract
Background and Objective: Recurrent pregnancy loss is a frustrating and heart-wrenching experience for both the patient and the physician. There is strong evidence that oxidative stress has a role in the pathogenesis of many human diseases and early aging processes. The aim of the study was to determine the impact of oxidative stress on recurrent pregnancies loss via the evaluation of the oxidative stress status in blood and placenta of women with recurrent missed miscarriage. Methods: This study was conducted at the Department of Physiology, College of Medicine, University of Duhok and Azady Teaching Hospital. Two groups of women were included: the 1st group was (88) patients women admitted to Gynecology and Obstetrics Department in Azady Teaching Hospital with confirmed diagnosis of missed miscarriage; for termination of pregnancy, it was subdivided into (73) patients with a history of recurrent missed miscarriage, and (15) patients with a previous one missed miscarriage. The 2nd group, (84) women, served as a control group, and subdivided into 3 subgroups: a. thirty pregnant women with matched gestational age, b. thirty apparently healthy non- pregnant women with matched women's age, c. twenty four apparently healthy full-term pregnant ladies with matched women's age . Serum total antioxidants capacity (TAC), serum and placental tissue oxidative stress biomarkers;, 8-iso prostaglandin F2α (8-Isoprostane), and inhibin A were measured using specific ELISA kits, Results: showed the significant increase in serum and placental tissue of 8-Isoprostane suggests that the oxidative stress is a feature of the patho-physiological changes and the damage of placental syncytiotrophoblast which had seen in recurrent missed miscarriage. Serum total antioxidants capacity and Serum inhibin A, were significantly lower in missed recurrent miscarriage group compared with the control group. Conclusion: Oxidative stress was found to be present in the group women with recurrent pregnancy loss which indicates its role as a cause of missed miscarriage, especially in those women with low concentrations of total serum antioxidants capacity and inhibin A.
Keywords
oxidative stress; Antioxidants; Recurrent Pregnancy loss. 8-Isoprostane; inhibin A

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