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Evaluation of the salivary biomarkers creatine kinase (CK) & blood urea nitrogen (BUN) activities before& after non surgical periodontal treatment in patients with chronic periodontitis | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 4, 2011, Pages 107-111 | ||
| Author | ||
| Maha Sh. Mahmood | ||
| Abstract | ||
| ABSTRACTBackground: Host responses to periodontal disease include the production of different enzymes that are released bystromal, epithelial or inflammatory cells into saliva & gingival crevicular fluid (GCF).Aim of the study: to assess the difference in the activity of CK &BUN enzymes in the saliva of male patients withchronic periodontitis before & after non surgical periodontal treatment & to evaluate the correlation between theseenzymes& probing pocket depth &relative attachment level.Materials & methods: Measurements of plaque index (PlI),gingival index(GI) , bleeding on probing (BOP) , probingpocket depth (PPD) &relative attachment level (RAL) were taken from male patients suffering from chronicperiodontitis before perio dontal treatment & one month after treatment .Saliva was collected for biochemical analysis of the enzymes creatine kinase & blood urea nitrogen.Results: The results have shown that after conventional periodontal therapy, the activity of these enzymes wassignificantly decreased .There was a correlation between the activities of these enzymes & probing depth .Also therewas a strong correlation between CK enzyme & relative attachment level.Conclusion: Based on these results, it can be assumed that the activity of these enzymes in saliva, as biochemicalmarkers for periodontal tissue damage, may be useful in the diagnosis, prognosis & evaluation of periodontal therapyeffects in periodontal disease.Keyword: Salivary markers, periodontal disease. (J Bagh Coll Dentistry 2011;23(4):107-111). | ||
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