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Immunohistochemical expressions of matrix metalloproteinase-9 and Vimentin in oral squamous cell carcinoma | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 4, 2009, Pages 54-58 | ||
| Authors | ||
| Ahlam H.Majeed; Afrah A.Khalil | ||
| Abstract | ||
| ABSTRACTBackground: Squamous cell carcinoma is a malignant neoplasm of stratified squamous epithelium; it occurs indifferent sites and has potential destructive growth and invasive with distant metastasis. The aims of the study wereto evaluate the expression of matrix metalloproteinase-9 and Vimentin immunohistochemistry and to correlate themwith the clinicopathological parameters in oral squamous cell carcinoma.Materials and methods: twenty prospective and eleven retrospective paraffin- embedded formalin- fixed blocks oforal squamous cell carcinoma were included in this study. Haematoxylin & Eosin stain (H & E) andimmunohistochemical staining was done by using monoclonal antibodies for anti-matrix metalloproteinase and anti-Vimentin.Results: positive immunohistochemical staining for MMP-9 was seen in 100% of collective cases while it was seen in93.5% for Vimentin.Conclusions:There was no correlation found between the two markers. MMP-9 expression was found in all cases withno correlation with clinicopathological parameters so it can be used as a diagnostic tumor marker rather than aprognostic marker. Vimentin was expressed in most OSCC cases with significant correlation with tumor size andstage. Vimentin can be used as a good prognostic tumor marker.Key word: Oral squamous cell carcinoma, Matrix metalloproteinase-9, Vimentin. (J Bagh Coll Dentistry 2009; 21(4):54-58). | ||
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