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Aurora B kinase expression in oral squamous cell carcinoma | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 3, 2009, Pages 96-98 | ||
| Authors | ||
| Lehah Al-Azzawi; Suha A.H. Hindy | ||
| Abstract | ||
| ABSTRACTBackground: The present study was conducted on oral squamous cell carcinoma(OSCC) which is the most commonoral malignancies with main objective of showing the expression of Aurora B in OSCC and its correlationto clinicopathological parameters.Materials and Methods: This study comprised a total of (65) patients diagnosed as OSCC,(48) males and (17) females.The cases include: well differentiated SCC.(32)cases, moderately differentiated SCC.(25) and poorly differentiatedSCC.(8)cases. The expression of Aurora B protein was carried out on 4μm tumor sections using Immuno histochemicalstaining of Aurora B antibody.Results: Results showed high expression of Aurora B in the most cases of OSCC with a mean expression about (48.66),in addition to that results showed that the expression of Aurora B was increased with the progression of histologicalgrade and stage of tumor.Conclusion: Aurora B over expression and its correlation with progression of tumor stage and grade may indicate theassociation of Aurora B expression with the aggressiveness of tumor.Key words: Oral squamous cell carcinoma, squamous cell carcinoma. (J Bagh Coll Dentistry 2009; 21(4):96-98) | ||
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