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A COMPARATIVE STUDY OF ORAL AND TOPICAL KETOCONAZOLE IN THE TREATMENT OF PITYRIASIS VERSICOLOR | ||
| Journal of University of Anbar for Pure Science | ||
| Article 2, Volume 1, Issue 2, 2007, Pages 1-9 PDF (356.86 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2007.15277 | ||
| Author | ||
| ABDULLAH S. HESSEN* | ||
| Department of Medicine, College of Medicine, Al-Anbar University | ||
| Abstract | ||
| : Objective:-The first purpose of the present work is in vivo (clinical study): A comparative study of oral and topical Ketoconazole in the treatments of P V and (second) in vitro (laboratory study): To determine the activity of Ketoconazole against M Furfur by (MIC) test. Study patients:- In vivo or clinical study included only one hundred and seventy eight outpatients. Each patient was examined clinically before treatment as well as by laboratory examination.. After treatment, cure was confirmed by wood’s light examination , 95 % of cases were no fluorescence while direct microscopic examination showed cure of first degree 64 % , 44 % , 40 % , 12 % in groups A , B , C , D respectively for yeast and for hyphae cure was100% ,100% , 100 % , 84 % in groups A , B , C , D respectively. Results: - With regard antifungal susceptibility test (MIC), our results showed that Ketoconazole was highly effective against 40 isolates of the fungus with MIC ranging from 0.03 – 0.5 µg/ml. MIC50 was 0.06 µg/ml and MIC90 was 0.25 µg/ml. However drug acts as fungicidal action (MFC) in 19 (47.5 %) of isolates and fungistatic action (MIC) in 21 (52.5 %) of isolates. The study concluded that ketoconazole was highly effective in vivo and in vitro., clinical trial reported the great cure in group A (200mg) followed by group B (400mg), then group C (2% cream) and group D (2% shampoo) was the less cure. Also, great side effect in group A followed by C, D then B. | ||
| Keywords | ||
| ketoconazole; Pityriasis versicolor; antifungal susceptibility testing | ||
| References | ||
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[1] S. L E. (1995). Tinea versicolor. Int. J. drermatol. 34:9. 611-617.
[2] N. A., et al. (2000). Identification of malassezia species isolated from patients with seborrheic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects. Med. Mycol. 38: 337.
[3] H. R.J. and M. M. (1998). Mycology. In: champion, R.H., Burton, J.L., Burns, D.A. and Breathnach, S.M.: Rook/Wilkinson/ Ebling. Textbook of dermatology, (6th) edition. Pp.1286-1290. vol. 2. Blackwell scientific publication, London.
[4] B.C.G. and G. L. (2002). Tinea versicolor. J. Medicine. Dec.2.
[5] K. K. J. and B.J.E. (1992). Medical Mycology. Lea and febiger, USA. Pp.81-100, 170-180
[6] E. J. C. (1995). Medical mycology. In: Boork, G.F., Butel, J.S. and ornston, L.N.: Jawetz, Melnick, and Adelberg's Microbiology, (20th) edition.P. 529-532. Middle East edition, Appelton and lang, California..
[7] NCCLS. (1997). Reference method for broth dilution antifungal susceptibility testing of yeast. Approved standard M27-A. National committee for clinical laboratory standards, wayne.
[8] F. B. A, S. D. F. and W.A.S. (1998). Bailey and Scott's diagnostic microbiology, (10th) edition. Mosby, Inc., Baltimore Bosten.
[9] K. C. Y., M. C.A., L. J.C., S. S.S. and J. A.O. (2004). In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and form control patients. Braz Oral Res. 18:1.
[10] H. K. A, C. C. F. and R. T. V. (2000). In vitro activities of ketoconazole, Econazole, Micronazole and Melaleuca alternifolia (Tea tree) oil against Malassezia species. Antimicrob agents and chemother. 44:2. 467-469.
[11] M. L., V. J., F. S. and F. A. (2004). Treatment of pityriasis versicolor in the United States. Int. J. dermatol. 15:3. 189-192.
[12] A. S. K. and M. P. H. (2003). Yeast infections: Candidiasis, pityriasis (tinea) versicolor. In: freedberg, I, M., Arthur, Z.E., Klaus, W., Austen, K.F., Goldsmith, L.A. and Katz, S.I.:Fitzpatrick's. Dermatology in General medicine, (6th) edition. P.2014-2016. Vol. 2. McGraw- Hill, New York.
[13] AL-R M.G. (1991). Clinico-epidemiological study of Pityriasis versicolor in Baghdad. MS.C. thesis. Department of community medicine, college of Medicine, university of AL-Mustasiriya.
[14] S. A. (1997). Malassezia furfur: A fungus belonging to the physiological skin flora and its relevance in skin disorders. Cutis. 59:21.
[15] B N F. (2004). Britsh National Formulary. Britsh Medical Association Royal pharmaceutical society of great Britain. 48 September. | ||
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