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Dental caries in relation to salivary parameters and immunoglobulins among Down's syndrome children in comparison to normal children | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 3, 2009, Pages 118-124 | ||
| Authors | ||
| Jassem T. Alkhafaji; Sulafa K. El-Samarrai; Nada J. Radhi | ||
| Abstract | ||
| ABSTRACTBackground: Low caries – experience in Down's syndrome individuals was observed. These observations have beenquestioned by many researchers whether they are inherently resistant to caries or not. Therefore, the aim of this studywas to measure the changes in the level of pH, flow rate, buffer capacity as well as IgA and IgG in stimulated salivaand their relation to dental caries among Down's syndrome children in comparison to normal children.Materials and Methods: Fifty institutionalized children with Down's syndrome and 50 normal children aged 7-10 yearsold were included in this study. DMFS and dmfs indices were assessed according to Muhlemann's criteria andstimulated whole saliva samples were collected. The average salivary flow rate was measured from the total volume,and salivary pH and buffer capacity was determined using pH meter. Salivary IgA and IgG levels were determinedby single radial immunodiffusion technique. All data were analyzed using SPSS version 13.Results: The DMFS and dmfs scores were significantly lower in Down's syndrome children than the control group (P<0.01, P< 0.001respectively). A slightly higher value of pH was found among study compared to the control group (P>0.05). Salivary flow rate was significantly lower in Down's syndrome children (P< 0.001), while buffer capacity wassignificantly higher in those group (P< 0.01). Salivary IgA and G were significantly higher in Down's syndrome children(P< 0.001).Conclusion: This study suggests that Children with Down's syndrome present a better buffer capacity which mayexplains a lower caries – experience compared to normal children.Key words: Down's syndrome, dental caries, salivary secretory IgA. (J Bagh Coll Dentistry 2009; 21(4):118-124) | ||
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