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Assessment of salivary flow rate and secretory immunoglobulin A and oral mucosal changes in acute myeloid leukemia before and after the induction phase of chemotherapy | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 3, 2009, Pages 82-89 | ||
| Authors | ||
| Mays Rafid; Sabah Saka; Hajer I. Abdullah | ||
| Abstract | ||
| ABSTRACTBackground: Acute myeloid leukemia (AML) is a hematological disorder characterized by the presence of immaturehematopoietic cells in the bone marrow and blood. These malignant cells do not differentiate normally, and thusmay block the differentiation of the remaining normal hematopoietic precursors. Chemotherapy is the treatment ofchoice of AML. The aim of the study was to determine the salivary flow rate and the S-IgA secretion rate in AMLpatients before and after chemotherapy and to assess oral mucositis after chemotherapy and to report any otheroral mucosal manifestations.Materials and Methods: A total of 40 patients just diagnosed as having acute myeloid leukemia participated in thestudy. The control group consisted of 20 healthy subjects. Clinical oral examination took place at the time of thediagnosis, and again one month following chemotherapy.Results: The most serious oral complication is the mucositis which developed in (52.5%) of AML patients afterchemotherapy. Before chemotherapy the salivary flow rate and S-IgA secretion rate were significantly lower thantheir values in healthy subjects (p<0.001and p<0.007), after chemotherapy, a further reduction in their values wasdetected. AML patients with oral mucositis presented with lower S-IgA level compared with their counterparts withno mucositis (p<0.02).Conclusion: Oral mucositis is a common and serious problem during chemotherapy. The salivary flow rate and S-IgAlevels are significantly reduced in AML patients undergoing chemotherapy which in turn affect general oral healthstatus.Keyword: Acute myeloid leukemia, chemotherapy, mucositis, salivary S-IgA. (J Bagh Coll Dentistry 2009; 21(4):82-89) | ||
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