H. Shehab, O. (2012). The effect of some Thiosemicarbazide derivatives and their complexes on Human Serum Cholinestrase Activity. , 3(2), 95-99. doi: 10.37652/juaps.2009.15370
Omar H. Shehab. "The effect of some Thiosemicarbazide derivatives and their complexes on Human Serum Cholinestrase Activity". , 3, 2, 2012, 95-99. doi: 10.37652/juaps.2009.15370
H. Shehab, O. (2012). 'The effect of some Thiosemicarbazide derivatives and their complexes on Human Serum Cholinestrase Activity', , 3(2), pp. 95-99. doi: 10.37652/juaps.2009.15370
H. Shehab, O. The effect of some Thiosemicarbazide derivatives and their complexes on Human Serum Cholinestrase Activity. , 2012; 3(2): 95-99. doi: 10.37652/juaps.2009.15370

The effect of some Thiosemicarbazide derivatives and their complexes on Human Serum Cholinestrase Activity

Journal of University of Anbar for Pure Science
Article 26, Volume 3, Issue 2, 2009, Pages 95-99    PDF (438.51 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2009.15370
Author
Omar H. Shehab*
University of Anbar - Education College for Women.
Abstract
The inhibitory effect of some 1-phenyl-3-methyl-5-pyrazolone thiosemicarbazone and 1-phenyl-3-methyl-5-pyrazolone-4-phenyl thiosemicarbazone and their complexes with Cr(III),Mo(V) and W(VI) on the activity of human serum cholinesterase have been studied in vitro. Some of these compounds showed a remarkable activity even at low concentration . From the degree of inhibition obtained, the time of incubation and inhibitor concentration for the highest inhibition have been determined. The results obtained from (Linweaver –Burk) plot indicates that the inhibition is Non-Competitive. The inhibition percentages obtained confirmed that the complexes has a higher inhibition than ligands.
Keywords
Thiosemicarbazide derivatives; complexes; human; Cholinestrase
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