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Assessment of serum and salivary oxidative stress biomarkers with evaluation of oral health status in a sample of autistic male children | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 3, 2011, Pages 56-60 | ||
| Authors | ||
| Raja H. Al-Jubouri; Mayyadah H. Rashid | ||
| Abstract | ||
| ABSTRACTBackground: Autism is a severe neurodevelopmental disorder, presents in early childhood, characterized by severeimpairments in socialization, communication and behavior. Autism is considered a multi-factorial disorder that isinfluenced by genetic, environmental, and immunological factors with oxidative stress as a mechanism linking thesefactors. Assessment of any oral manifestations; measurement of oxidative stress in saliva has to be discovered,evaluated and measured in autistics to be used as a potential diagnostic aid since saliva is an ultra-filtrate of serumand meet the demand for inexpensive, noninvasive and accessible diagnostic methodology.Materials and methods: Oral health status: DMFT/dmft and gingival indices as well Serum and salivaryMalondialdehyde (MDA) levels , glutathione (GSH), superoxide dismutase (SOD) and uric acid (UA) were estimatedfor 58 individuals aged (2-13) years, twenty nine of them were autistics and twenty nine were sex and age matchedhealthy controls.Results: The results of this study showed that Iraqi autistic children sample was more likely to be caries-free, withsignificant abnormalities of the oxidative stress biomarkers.Conclusion: Saliva can be used as adjunctive diagnostic aid for measurement of the oxidative stress in autism. SerumGSH and uric acid then serum and salivary Malonyldialdehyde followed by salivary glutathione and serumsuperoxide dismutase are the most powerful predictors of autism spectrum disorder respectively.Key words: Autism spectrum disorder; Oxidative stress; Oral health status. (J Bagh Coll Dentistry 2011;23(3): 56-60). | ||
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