- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Preparation and identification of some a new derivative for Trimethoprim drug | ||
| Journal of University of Anbar for Pure Science | ||
| Article 16, Volume 3, Issue 3, 2009, Pages 48-53 PDF (821.64 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2009.15578 | ||
| Author | ||
| Sanaa A.Al-Sahib* | ||
| Baghdad University- College Science for women | ||
| Abstract | ||
| In this reaction new derivatives for Ttrimetheprim compound, which have high medicinal effectiveness, was prepared by the interaction of its coupling diazonium salt with some substituted phenol compounds (2-naphthol , 4-bromo phenol, 2,5-dimethoxy phenol ,2,4-dinitro phenol , 3-chloro phenol.Chemical structures of all products were confirmed by photometric methods such as U.V. visible and FTIR.The biological activities was also examined for these compounds.Gram + ve bacteria (bacillus) , Gram –ve bacteria (E-Coli) and fungi (Aspiringussb). | ||
| Keywords | ||
| preparation; identification; derivative; trimethoprim | ||
| References | ||
|
1- Dr. Karl Thomae GmbH (Biberach an der Riss, DE), United States Patent,4829058., Substituted bis-(4-aminophenyl)-sulfones, Publication Date:05/09/1989 , International Classes: C07C205/26; C07C205/34; C07C205/00; C07C103/22 .
2- S.R.M. Bushby and C.W.Sigel ,J.Med .Chem.,24,933 (1981). And refernces cited therein.
3- Bean DC, Livermore DM, Papa I, Hall LM (November 2005). "Resistance among Escherichia coli to sulphonamides and other antimicrobials now little used in man". J Antimicrob Chemother 56 (5): 962–4.
4- The British Pharmacopoeia 2007.
5- UHRICH, Kathryn, E.; Patent (WO/2002/009769) THERAPEUTIC AZO-COMPOUNDS FOR DRUG DELIVERY.
6- Christos Haritoglou, Alice Yu, Wolfgang Freyer, Siegfried G Priglinger, Claudia Alge, Kirsten Eibl, Christian A May, Ulrich Welge-Luessen, Anselm Kampik, An evaluation of novel vital dyes for intraocular surgery. Vis Sci. 2005 Sep; 46 (9):3315 Germany.
7- Haubrich .H, and Galinke .1960. "coupling activity of heterocyclic diazo compounds". Chem. Ber, 93,397. Abs, 121118h.
8- H.Al-Badre.2007. "study and synthesis of new 2-amino-5-thiodiazole derivative "M.Sc Thesis: University of Baghdad.
9- Encyclopædia Britannica Article. Chemical Compound: Azo Dyes. http://www.britannica.com/eb/article-79849/chemical-compound (accessed June 2007).
10- M. Wang, K. Funabiki, M. Matsui, Synthesis and properties of bis(hetaryl)azo dyes, Dyes and Pigments, 2003, 57, 77-86.
Silverstein .G.T., 1981. Spectrometric identification of organic copounds., 4Ed . | ||
|
Statistics Article View: 584 PDF Download: 495 |
||