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Evaluation of salivary immunoglobulin A and interleukins IL-1 alpha and IL-8 in psoriatic patients with and without geographical tongue | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 3, 2009, Pages 76-81 | ||
| Authors | ||
| Tania Faeq; Sabah Saka; Hajer I. Abdullah | ||
| Abstract | ||
| ABSTRACTBackground Psoriasis is a common chronic inflammatory skin disorder presenting in various clinical types. Oral lesionsin psoriasis patients are rare and have been clinically presented described as white plaques, erythematous patches,or ulcerations. An increased prevalence of erythema migrans has been reported.Aims of the study This study was designed to evaluate the relationship between psoriasis and geographical tongueand determine the salivary secretory immunoglobulin A (S-IgA), IL1α and IL8 in psoriasis patients, as well.Materials and methods Clinical oral examinations had been done for fifty patients with psoriasis as well as fifty, ageand gender, matched control subjects for detecting the presence of geographical tongue and report any oralmucosal changes. Samples of whole unstimulated mixed (resting) saliva were collected from all participants theninvestigated for the level of SIgA, IL-1α and IL-8 by Enzyme Linked Immunosorbent Assay (ELISA).Results: The incidence of geographical tongue was higher among psoriasis patients (20%), in comparison to controlgroup which was (4%).The mean value of salivary IgA was reduced in psoriasis patients, with and withoutgeographical tongue cases. But the reverse result appeared with IL1α and IL8. This picture reflects a clearimmunological background for geographical tongue that goes at the same direction of psoriatic immunopathology.Conclusion: Geographical tongue could be an oral manifestation of generalized pustular psoriasis. Psoriasis patientsshowed significantly lower concentrations of salivary IgA compared to control.Key words: Psoriasis, Geographical tongue, salivary secretory IgA, Interlukins. (J Bagh Coll Dentistry 2009; 21(4):76-81) | ||
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