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The study of oral manifestations, oxidative stress marker and antioxidants in serum and saliva of rheumatoid arthritis patients | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 3, 2011, Pages 74-79 | ||
| Authors | ||
| Tagreed F. Zaidan; Zahra K. Hadi | ||
| Abstract | ||
| ABSTRACTBackground: Rheumatoid arthritis (RA) is a heterogeneous disease with a spectrum of clinical severity ranging frommild arthritis to a crippling joint disorder with internal organ involvement. Besides the immunological reaction, there isanother biological process, based on the injurious activity of free radicals, playing a major role in the pathogenesis;an increase in the generation of oxidants and lipid peroxidation products was demonstrated in the serum of RApatients, which correlated with the antioxidant levels.Subjects, Materials and Methods: Seventy six individuals were enrolled in this study; Fifty one of them were patientshaving RA; twenty five were healthy control individuals matching the patients in age and sex. Serum and salivasamples have been taken from each subject for biochemical analysis.Results: The highest number of RA patients was of mild disease activity, while the lowest number was of inactivedisease activity. Xerostomia was the most prominent oral manifestations of RA patients. The mean of serum andsaliva MDA and UA in RA patients was significantly higher than of the healthy controls. The mean of serum and salivacaeruloplasmin in RA patients was higher than that of the healthy controls.Conclusion: Rheumatoid arthritis patients were associated with increased oxidative stress, antioxidants andinflammatory markers.. Patients with RA have different oral manifestations xerostomia were the most prominent. Thehighest number of RA patients was of mild disease activity.Key words: rheumatoid arthritis, oxidative stress, DAS, saliva flow rate. (J Bagh Coll Dentistry 2011;23(3): 74-79). | ||
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