Oxidative stress marker malondialdehyde and antioxidants superoxide dismutase and uric acid in ischemic heart disease patients

A. Mahmood, Rehab; F. Zaidan, Taghreed; M. Shaheed, Alaa

	Oxidative stress marker malondialdehyde and antioxidants superoxide dismutase and uric acid in ischemic heart disease patients
Journal of baghdad college of dentistry
Article 1, Volume 21, Issue 3, 2009, Pages 65-71
Authors
Rehab A. Mahmood; Taghreed F. Zaidan; Alaa M. Shaheed
Abstract
ABSTRACTBackground: When the oxidant-antioxidant balance is disturbed in favour of reactive oxygen species (ROS),oxidative stress occurs, which is damaging to tissues. Oxidative stress and ROS have been reported to be related tothe pathogenesis of many diseases including ischemic heart diseases. The aim of this study was to assess oxidativestress marker malondialdehyde (MDA) and the antioxidants uric acid (UA) and superoxide dismutase (SOD) in serumand saliva of ischemic heart diseased patients.Materials and Methods: Eighty subjects were enrolled in this study, forty patients were diagnosed as ischemic heartdisease (IHD), their ages ranged between 42-80 years, and forty individuals were age and sex matched healthylooking volunteers. MDA, UA and SOD have been estimated for all the serum and salivary samples.Results: The mean levels of serum and salivary MDA, UA, and SOD in IHD patients were higher than that of healthycontrols. Age was the most important explanatory factor that affects salivary MDA, UA, and SOD.Conclusions: Ischemic heart disease patients are associated with increased oxidative stress which has beenrepresented by increased MDA levels and increased antioxidants UA and SOD in serum and saliva.Key words: Ischemic heart diseases, oxidative stress, malondialdehyde, superoxide dismutase, uric acid. (J Bagh CollDentistry 2009; 21(4):65-71)

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