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A Comparative Study of Salbutamol Nebulizer versus Ipratropium Bromide plus Salbutamol Nebulizer in the Treatment of Children with Acute Asthma Exacerbation | ||
| karbala journal of pharmaceutical sciences | ||
| Article 13, Volume 9, Issue 15, 2018, Pages 122-137 PDF (0 K) | ||
| Authors | ||
| Aqeel M. Hussein; Ali H. Hanoon; Ahmed Mahmoud AL-Tuama; Haidar A. N. Abood | ||
| Abstract | ||
| Background: Patients with asthma may develop acute attack due to different types of triggering factors. Early recognition of an acute asthma exacerbation is crucial for effective management. Objectives: To evaluate the effects of salbutamol nebulizer versus salbutamol plus ipratropium bromide nebulizer in children with acute asthma exacerbation attack. Patients and methods: A randomized double blind standard control clinical study was conducted in Karbala Teaching Hospital for Children from 1st of November 2015 to the end of November 2016 on patients presented to the emergency room (ER) of the Hospital. The study was conducted on hundred patients presented with mild to moderate acute attacks of asthma, assigned to take either nebulized salbutamol or combination of salbutamol plus ipratropium bromide during their stay. Assessment of asthma severity was done for each patient according to pulmonary index score (PIS) Results: There was significant reduction (p <0.05) in PIS for patients treated with salbutamol alone and patients treated with combination therapy (ipratropium + salbutamol) after 30,60 and 90 minutes from ER admission as compare with their scores at baseline, 30 and 60 minutes respectively. After 30 minutes from ER admission, patients who were treated with combination of ipratropium bromide + salbutamol had significantly (p <0.05) lower PIS (5.60±2.77) than those treated with salbutamol alone (PIS=7.32±2.18). The mean duration of stay in ER was significantly (p <0.05) shorter in patient treated with combination therapy (57.60±21.71 min) than those with salbutamol alone (77.40±16.13 min). Conclusion: Treatment of asthmatic children with mild to moderate acute exacerbation attack with combination therapy of (ipratropium plus salbutamol nebulizer) improved the clinical condition, lowered pulmonary index score, and significantly shortened the duration of stay in emergency room as compared with salbutamol nebulizer alone.. | ||
| Keywords | ||
| Ipratropium Bromide; Salbutamol; Childhood asthma; Acute Asthma Exacerbation | ||
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