Synthesis and Study of Many New Chalcone Derivatives

G. Ahmad, Natiq; H. Ali, Murtatha

doi:10.33899/edusj.2018.159283

	Synthesis and Study of Many New Chalcone Derivatives
Journal of Education and Science
Article 1, Volume 27, Issue 4, 2018, Pages 1-28 PDF (0 K)
DOI: 10.33899/edusj.2018.159283
Authors
Natiq G. Ahmad; Murtatha H. Ali
Abstract
This study include the synthesis of the compound 1-(1H-benzo[d]imidazol-2-yl)ethanol [1], from the reaction of ortho pheneylene diamine with lactic acid and then oxidized using potassium dichromate to give1-(1H-benzo[d]imidazol-2-yl) ethanone [2]. Reaction of this compound with different substituted benzaldehydes or 1-(1H-benzo[d]imidazol-2-yl)ethanone, to obtain α, β-unsaturated carbonyl compounds (chalcones) [3-11]. These chalcones have been used in preparing number of heterocyclic compounds through reaction with the hydrogen peroxide to get the oxiran compounds (three membered rings) [12-20], hydroxyl amine hydrochloride to prepare the isooxazoline compounds(five membered rings) [21-29], 3-nitrobenzohydrazide to prepare the pyrazoline compounds(five membered rings)[30-38], thiosemicarbazide hydrochloride to prepare the pyrazoline compounds(five membered rings) [39-47], semicarbazide to prepare the pyrazoline compounds(five membered rings) [48-56], guanidine nitrate to prepare the pyrimidine compounds(six membered rings) [57-65], ortho pheneylenediamine to prepare the benzodiazepine compounds (seven membered rings) [66-74], ortho aminophenol to prepare the benzoxazepine compounds(seven membered rings) [75-83]. The synthesized compounds were identified, using chemical, physical and spectral methods (melting points, color change, infrared spectra, ultraviolet spectra, nuclear magnetic resonance spectra and many theoretical studies).
Keywords
Chalcone Derivatives; potassium dichromate; benzo

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