Synthesis and Evaluation the Activity of 1,3,4-Thiadiazole Derivatives as Antibacterial Agent Against Uncommon Bacteria Causes of Urinary Tract Infections

Daham, Shaymaa; Abdullwahab, Marwa H.; Mahmood, Asmaa E.; Akram, Evon

doi:10.33899/rjs.2018.159340

	Synthesis and Evaluation the Activity of 1,3,4-Thiadiazole Derivatives as Antibacterial Agent Against Uncommon Bacteria Causes of Urinary Tract Infections
Rafidain Journal of Science
Article 11, Volume 27, Issue 4, 2018, Pages 90-102 PDF (757.46 K)
DOI: 10.33899/rjs.2018.159340
Authors
Shaymaa Daham^* ¹; Marwa H. Abdullwahab²; Asmaa E. Mahmood³; Evon Akram⁴
¹Department of Biology, College of Education, University of Samarra
²Department of Biology, College of Science, University of Tikrit
³Department of Pathological Analyzes, College of Applied Sciences, University of Samarra
⁴Department of Chemistry, College of Science, University of Al-Nahrain
Abstract
Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. New Schiff bases react with copper (II), Ferric (III), Cobalt (II) and Zinc (II) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper (II) LM1, Ferric (III) LM2, Cobalt (II) LM3 and Zinc (II) LM4 complexes) were studied against Kocuria kristinae, Alloiococcus otiti and Aerococcus urinae as a model of Gram positive, Pseudomonas stutzeri, Ochrobactrum anthropic and Pantoea agglomerans as a model of Gram negative to determine the activity of synthesized complexes. Identification of these uncommon bacteria that isolated from urinary tract infection confirmed by using VITEK2 compact system. Several antibiotics have been chosen to investigate the ability of these isolates to resist the conventional antibiotic. The results showed higher activity of the new compounds relative to the chosen antibiotics. .
Keywords
synthesis; thiadiazole; uncommon bacteria; Antibiotic; antibacterial agent

Statistics Article View: 562 PDF Download: 506