Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats

Mohammed, Sulaf Mustafa; Ibrahim, Majida Noori; Ahmed, Mahmood Othman

doi:10.33899/ijvs.2019.125528.1050

	Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats
Iraqi Journal of Veterinary Sciences
Article 4, Volume 33, Issue 1, 2019, Pages 21-26 PDF (892.14 K)
Document Type: Research Paper
DOI: 10.33899/ijvs.2019.125528.1050
Authors
Sulaf Mustafa Mohammed¹; Majida Noori Ibrahim^* ²; Mahmood Othman Ahmed¹
¹Biology department, College of Science, University of Sulaimani
²Biology department, College of Science, University of Kirkuk
Abstract
The aim of this study was to investigate the ameliorative effect of Broccoli against lead acetate (PbA) hepatotoxicity by some physiological and histological indicators. The results showed that intraperitoneal (I.P.) injection by 12 mg/kg body weight of lead acetate once a week for 8 weeks led to an increase in the activity of Glutamate pyruvate transaminase (GPT), Glutamate oxaloacetate transaminase (GOT), Alkaline phosphatase (ALP), Acid phosphatase (ACP), Total serum protein (TP) and Total serum bilirubin (TSB). Liver's histological sections of lead acetate injected rats showed infiltration of inflammatory cells with sinusoid dilation, necrosis, and apoptosis of Kupffer cells. Broccoli has an ameliorative effect, that the physiological parameters and histological examination have been showed an improvement. In conclusion, lead acetate produces hepatic disorder and the potential use of Broccoli as a source of natural antioxidants or nutraceuticals protects against lead acetate hepatic toxicity.
Keywords
Broccoli; Lead; liver function; Liver histology; Histopathology

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