Protective effect of Silymarin against kidney injury induced by carbon tetrachloride in male rats

Ahmed, Measer Abdullah; Tayawi, Hussien Mohammad; Ibrahim, Mohammed Khalil

doi:10.33899/ijvs.2019.125529.1051

	Protective effect of Silymarin against kidney injury induced by carbon tetrachloride in male rats
Iraqi Journal of Veterinary Sciences
Article 21, Volume 33, Issue 1, 2019, Pages 127-130 PDF (756.38 K)
Document Type: Research Paper
DOI: 10.33899/ijvs.2019.125529.1051
Authors
Measer Abdullah Ahmed^* ¹; Hussien Mohammad Tayawi²; Mohammed Khalil Ibrahim²
¹Department of Biology, College of education for pure science, Tikrit university , Iraq.
²Department of Biology, College of Education for Pure Science, Tikrit university, Tikrit - Iraq
Abstract
The herbal drugs have a protective effect for kidney function against chemical toxicity. 24 male rats divided into 4 groups and treated as following, control group administrated orally with 1ml/kg. B.W physiological solution (0.9%), One dose Carbon Tetrachloride (CCl₄) 3 ml/kg. B.W, Silymarin 150 mg/kg. B.W and Silymarin150 mg/kg. B.W with CCl₄ 3 ml/kg. B.W for 30 days. Oxidative stress resulted by CCl₄ caused increasing in Creatinine, Urea, total protein, Albumin, malondialdehyde (MDA) levels decreasing in Glutathione (GSH) and superoxide dismutase (SOD) levels in serum and congestion, degeneration and desquamation in kidney tissue. We concluded that Silymarin showed protective effect via increasing GSH, decreasing creatinine, Urea, total protein and MDA levels in serum and protect kidney tissue in rats.
Keywords
Silymarin; CCl4; Kidney toxicity; Antioxidant

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