Protective effects of coenzyme Q10 against sodium fluoride-induced reproductive disorders in male rats

Momammed Ali, Sabreen M.; Nowfal, Ahmed Jasim; Abdillah, Bara Najim

doi:10.33899/ijvs.2019.125534.1056

	Protective effects of coenzyme Q10 against sodium fluoride-induced reproductive disorders in male rats
Iraqi Journal of Veterinary Sciences
Article 24, Volume 33, Issue 1, 2019, Pages 143-149 PDF (1009.68 K)
Document Type: Research Paper
DOI: 10.33899/ijvs.2019.125534.1056
Authors
Sabreen M. Momammed Ali^* ¹; Ahmed Jasim Nowfal²; Bara Najim Abdillah³
¹Department of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine /University of Baghdad, Baghdad - Iraq.
²Department of Physiology, College of Medicine, University of Al-Falloja, Al-Falloja - Iraq
³Department of Physiology, Biochemistry and Pharmacology/College of Veterinary Medicine / University of Baghdad. Baghdad- Iraq.
Abstract
This study was conducted to investigate the possible protective role of (CoQ10) on reproductive dysfunction of male rats induced by sodium fluoride (NaF). thirty two rats were divided into four even groups and treated for 56 days as follows: the first group served as control (C) The second group (G1) received coenzyme Q10 at dose of 10 mg/Kg.B.W; while third group (G2) received 100ppmsodium fluoride in drinking water and fourth groups (G3) received NaF 100 ppm and CoQ10 10 mg/Kg.B.W for 56 days. The results showed that exposure of rats to NaF caused decrease in serum testosterone (T) and luteinizing hormones (LH) concentrations. Whereas Administration of CoQ10 caused an increase the concentrations of theses hormones in group G3 as compared with group G2. Testicular morphometric and histopathological alterations were observed in group G2 in the form of marked microvacuolation in the basal level of germinal cells, amyloid deposited within seminiferous tubules with disarrangement and depletion of germ cells. Whereas testicular histological alterations were improved in rats treated with CoQ10. In conclusion, the results of the present study showed that use of Co Q10 can alleviating the deleterious effects on male reproductive function following exposure to NaF, may be via improvement the testicular functions or other related endocrine glands.
Keywords
Sodium fluoride; Coenzyme Q10; Testosterone; Testicular morphometric; Rats

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