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Synthesis and Characterization of Some Novel Hydrazones of N-{11H-pyrido[2,1-b]quinazolin-11-one-9-yl} hydrazine | ||
| Rafidain Journal of Science | ||
| Article 15, Volume 28, Issue 2, 2019, Pages 135-145 PDF (370.28 K) | ||
| DOI: 10.33899/rjs.2019.159971 | ||
| Authors | ||
| Attallah M. Sheat; Rafid K. Jameel | ||
| Abstract | ||
| The 2-[(6-chloro-2-pyridyl) amino]benzoic acid (I) was synthesized viaUllmann-Goldberg coupling by reaction of anthranilic acid with2,6-dichloropyridine. The compound (I) was cyclized by using poly phosphoric acid (PPA) to give 9-chloro-11H-pyrido[2,1-b]quinazolin-11-one (II). The compound (II) reacted with hydrazine hydrate to give N-{11H-pyrido[2,1-b]quinazolin-11-one-9-yl} hydrazine (III). The compound (III) reacted with various aromatic aldehydes to yield the hydrazones (IVa-p). The reaction progress was followed by thin layer of chromatography (TLC). The physical constants and Rf values were recorded. The synthesized compounds were confirmed via the spectral data (UV,I.R,1H-NMR, 13C-NMR, mass spectra). The possible fragmentation pattrene of GC/MS for the compounds (IVa) were investigated (IVh).). | ||
| Keywords | ||
| anthranilic acid; pyridoquinazoline; hydrazine; Hydrazones | ||
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