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Spectrophotometric Determination of Mesalazine | ||
| Rafidain Journal of Science | ||
| Article 14, Volume 28, Issue 2, 2019, Pages 127-134 PDF (234.67 K) | ||
| DOI: 10.33899/rjs.2019.159982 | ||
| Author | ||
| Safaa A. Al-Zakaria | ||
| Abstract | ||
| Mesalazine (MESA) is determined by a simple and rapid visible spectrophotometric method. This method is depend on oxidative coupling reaction of mesalazine with histidine (HIS) in alkaline media using N-bromosuccinimide (NBS) as oxidizing agent to form a water soluble and stable product, that it has a maximum absorption at 459 nm. Beer's law is followed in a concentration range of 50 to 750 μg /20ml (2.5-37.5 μg /ml) with a molar absorptivity of 3.3682×103 l.mol-1. cm-1. The recommended method has been successfully applied to the assay of MESA in pharmaceutical preparations. | ||
| Keywords | ||
| rhodanese; spectrophotometry; Oxidative Coupling; sulfate oxidase; Mesalazine; thiosulfate oxidase; arylesterase; histidine; Renal failure | ||
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