HEMATOLOGICAL PROFILE OF RATS TREATED WITH QUERCETIN DERIVATIVE AGAINST CARBON TETRACHLORIDE (CCL4 ) TOXICITY

doi:10.33762/bvetr.2018.160398

	HEMATOLOGICAL PROFILE OF RATS TREATED WITH QUERCETIN DERIVATIVE AGAINST CARBON TETRACHLORIDE (CCL4 ) TOXICITY
Basrah Journal of Veterinary Research
Article 6, Volume 17, Issue 2, 2018, Pages 70-84 PDF (251.46 K)
Document Type: Research Paper
DOI: 10.33762/bvetr.2018.160398
Abstract
The effect of quercetin derivative (1-(-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4 H –chromen-4-ylidene) thiourea coded (QTU) on the hematological profile of Wistar rats induced toxicity with carbon tetrachloride (CCl4) was investigated. Administration intraperitoneal injection of 12.5 mg /kg and 25mg/kg of quercetin derivative (QTU), after four weeks of being exposed to CCl4, led to a significant decrease (p<0.05) in WBC count, with a corresponding increase on PCV and Hb. It was also observed that the functional recovery of these blood indices is concentration dependent. Results of this study revealed a depletion of RBC and a decrease in Packed Cell Volume (PCV) and Hemoglobin (Hb), In addition, an elevation in the levels of White Blood Cell (WBC) caused by CCl4 compared to control samples.
Keywords
Hematology; quercetin derivative; Carbon tetrachloride toxicity

Statistics Article View: 222 PDF Download: 488