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High Performance Liquid Chromatographic Method for Determination of Tadalafil in Tablets and Wastewater | ||
| Iraqi Journal of Pharmacy | ||
| Article 11, Volume 14, Issue 1, 2014, Pages 87-94 PDF (404.16 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/iphr.2019.161198 | ||
| Author | ||
| Nief Rahman Ahmed | ||
| Department of Environmental Technology, College of Environmental University of Mosul, Mosul-Iraq | ||
| Abstract | ||
| Objective: A reverse phase high performance liquid chromatographic method (RP-HPLC) has been developed for the determination of tadalafil in the pharmaceutical formulations and environmental wastewater samples. Method: Different analytical columns with various stationary phases were tested. Good separation was achieved using supelcoC18 column (25cm x 4.6 mm. 5 µm) . The mobile phase (methanol: water: Triethylamine) , pH adjusted to 4.0 with dilute phosphoric acid was pumped at a flow rate of 1.3 ml/min in the ratio of 60:38:2 and the peaks were detected at 220 nm. Results: Linearity was obtained in the concentration range of 0.0 4-0.28 mg/ml .The RSD was found to be less than 1% indicating the method is precise and the recovery was100±1.25% indicating the method is accurate Conclusion: The proposed HPLC method may be used for determining tadalafil in pure drug samples , pharmaceutical dosage forms and environmental wastewater samples. | ||
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