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Evaluation of non surgical treatment of chronic periodontitis by assessment the enzymatic activity | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 2, 2011, Pages 93-96 | ||
| Authors | ||
| Hayder S. Baker; Maha Shukri | ||
| Abstract | ||
| ABSTRACTBackground: Host responses to periodontal disease include the production of different enzymes that are released bystromal, epithelial or inflammatory cells into saliva and gingival crevicular fluid. There are important enzymesassociated with cell injury and cell death like: lactate dehydrogenase (LDH), creatine kinase (CK), alkalinephosphatase (ALP), gama glutamyl transferase (GGT). Changes in enzymatic activity reflect metabolic changes inthe gingiva and periodontium in inflammation.To assess the difference in the activity of LDH, GGT and ALP enzymes in the saliva of male patients with chronicperiodontitis before and after treatment, to test the effectiveness of treatment and to evaluate the correlationbetween these enzymes and the clinical parameters used for evaluation of periodontal tissues.Materials and Methods: Measurements of plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probingpocket depth (PPD) and clinical attachment level (CAL) were taken from ten subjects before treatment and onemonth after treatment; Only male were included and saliva was collected for biochemical analysis of the enzymesalkaline phosphatase ALP, lactate dehydrogenase LDH, and gamma glutamyle transferase GGT.Results: Obtained results have shown that after conventional periodontal therapy, the activity of all salivary enzymeswas significantly decreased. However there was no correlation between the activities of these enzymes and theclinical periodontal parameters except between LDH with bleeding on probing and clinical attachment level.Conclusion: Based on these results, it can be assumed that activity of these enzymes in saliva, as biochemicalmarkers for periodontal tissue damage, may be useful in the diagnosis, prognosis and evaluation of periodontaltherapy.Key words: Saliva, enzymes, periodontal disease. (J Bagh Coll Dentistry 2011;23(93-96). | ||
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