Overexpression of  p53 gene has an important role in induction and progression of breast carcinoma

, Hussein. A. Al-hamadawi; , Assad. A. Al-Janabi; , Adnan.w. Al-bideri

	Overexpression of p53 gene has an important role in induction and progression of breast carcinoma
Al-Qadisiah Medical Journal
Article 1, Volume 12, Issue 1, 2016, Pages 77-85 PDF (0 K)
Authors
Hussein. A. Al-hamadawi; Assad. A. Al-Janabi; Adnan.w. Al-bideri
Abstract
Breast cancer is the most common cancer in women, accounting for 23% of all female cancers around the globe. breast cancer molecular disease occurs due to the alteration in the genes that control cell growth and proliferation , such as HRE2/neu, c-MYC, K-RAS, RB, P53,PTEN,BRCA1 and BRCA2. The p53 tumor suppressor gene is located on chromosome 17p13, consists of 11 exons and encodes a53-kDa nuclear phosphoprotein, that has a very important function in many cellular processes, such as cell-cycle control, DNA repair , apoptosis and gene transcription. p53 is the most common mutated gene in human cancers , including breast. The aim of this study was to study the correlation between the overexpression of p53 and clinicopathological parameters in breast cancer patient. The current study included 85 sample of Paraffin-embedded breast cancer tissues, which were analyzed for p53 overexpression by immunohistochemistry. We also studies correlation between p53 overexpression and clinicopathological parameters. The results have clarified that 64.7% (55 out of 85) of cases of breast cancer had high expression of P53 immunostaining in their histological sections ,while 35.3% of cases were negative for p53 expression. The p53 expression was significantly correlated high grade and stage as well as age group less than 50 years ,and there was no significant correlation between p53 expression and gender of patient, lymph node status, tumor size, tumor site and histological types. Conclusion: These results demonstrated the overexpression of p53 in more than half of breast cancer cases and that overexpression of p53 was well correlated with grade and stage as well as young age group less than 50 years breast cancer patients. .

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