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Changes in blood parameters and kidney histology due to cadmium and selenium exposure of Female rat | ||
| Journal of Education and Science | ||
| Article 7, Volume 20, Issue 2, 2007, Pages 57-63 PDF (576.92 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2007.162801 | ||
| Author | ||
| Ahmed Ali | ||
| Abstract | ||
| The purpose of the study was to investigate the effect of Cadmium and selenium on blood parameters and the subsequent effect in the tissue of female rat kidney . Female rats were divided into a control group and tow experimental groups treated with Cadmium, and Cadmium +Selenium. A control and tested animals were fed with the same standard chow , but Cadmium chloride, and Cadmium+ Selenium mixture were orally gavaged daily for 28 days .At the end of the experimental period, blood samples were analyzed ,and packed cell volume ( PCV % ) , hemoglobin ( Hb ) , number of total erythrocytes count and total leucocytes count were determined . Blood analyses carried out in the present study showed that cadmium treatment causes different alterations in blood parameters as indicated by significant decrease in erythrocytes count , hemoglobin value and packed cell volume percentage as compared to control and Cd+selenium treated group . A number of histopathological change were observed in the kidney , including glomerular shrinkage, karyolysis , degenerative cell and cell necrosis at cadmium treatment and pronounced recovery after selenium cosupplemented showing a considerable antagonistic effects of Selenium + cadmium treatment . It can be concluded that the Cd exposure impair certain hematological mechanism and increase kidney tissue damage .Selenium showed beneficial effects to some extend. This study provide data on toxic effect in female rats after dietary sub lethal supplementation to heavy metals. | ||
| Keywords | ||
| cadmium; blood parameter; Histopathology | ||
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