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Spectrophotometric Determination of Benzocaine by Azo-Dye Formation Reaction with N - (1-naphthyl)ethylenediamine as Coupling Agent | ||
| Journal of Education and Science | ||
| Article 4, Volume 17, Issue 3, 2005, Pages 48-60 PDF (797.65 K) | ||
| DOI: 10.33899/edusj.2005.162863 | ||
| Authors | ||
| W. A. Bashir; N. S. Othman | ||
| Abstract | ||
| A simple spectrophotometric method for the determination of benzocaine in aqueous solution is developed. The method based on the coupling of diazotized benzocaine with N-(1-naphthyl)ethylenediamine(N-NED) in acidic rnedium. The purplish - violet azo dye formed is water soluble, stable, and shows tnaximum absorption at 547.5 nm. Beer's law is obeyed over the range 10 - 100 ptg I 25 ml, i.e, 0.4 - 4 ppm with a molar absorptivity of 5.56 x 104l.mol-r.cm-' and Sandell's sensitivity index of 0.0029 pg.cm-2, arelative error of - 0.660 to * 0.002% and a relative standard deviations of*0.110to+ 0.550% depending on the concentration. The method has been applied to determine benzocaine in two synthetic pharmaceutical preparations. | ||
| Keywords | ||
| Benzocaine; ethylenediamine; Coupling Agent | ||
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