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Analgesic effect of silymarin in chicks | ||
| Iraqi Journal of Veterinary Sciences | ||
| Article 16, Volume 33, Issue 2, 2019, Pages 273-276 PDF (652.83 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2019.162906 | ||
| Authors | ||
| Ahmed Salah Naser* 1; yasser albadrany2 | ||
| 1Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| 2Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| There were no studies about the analgesic effect of silymarin in the chicken. This study examined antinociceptive effect of silymarin given intraperitonially in 7-9 day-old chicks. The median effective dose of silymarin for the induction of analgesia to electric stimulation in the chicks was 65.3 mg/kg. Silymarin at 60, 120 and 240 mg/kg revealed analgesic effect to electric stimulation in chicks in dose dependent manner in comparison with the control group. The analgesic effect of silymarin at 120 and 240 mg/kg started at 15 min after injection and lasted after over 120 min of injection were as silymarin at 60 mg/kg the analgesic effect started at 15 min after injection and declined before 120 min of injection. The peak of analgesic effect for 60, 120 and 240 mg/kg were at 60 min after injection. These results indicate that silymarin have an analgesic property in the chicks model. | ||
| Keywords | ||
| Silymarin; Analgesia; chicks; Electrostimulation | ||
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