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Nucleolar organizer regions in giant cell lesions of the jaws in relation to clinico-pathological parameters | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 20, Issue 2, 2008, Pages 67-70 | ||
| Author | ||
| Balkees T. Garib | ||
| Abstract | ||
| ABSTRACTBackground: The aim of this study was to clarify the proliferatiove activity of the multinucleated giant cells and cellular component in giant cell lesions of the jaw in correlation to their clinico-pathological features.Materials and methods: This study was carried on 23 cases diagnosed as GC lesion of the jaw. Patient's personal and clinical information were collected from their files. H&E and sliver nitrate stains were applied on their formalin fixed paraffin embedded tissue sections.Results: The mean AgNOR count in MGC/cell was 49.83 and NORs/nucleus was 5.8, and 74% of them were grouped in large clusters and 26% were scattered. In PGCG the mean AgNOR count /MGC and /nucleus were significantly lower than that of CGCL (38.2 vs 59.5 and 4.6 vs 6.8 respectively, P<0.04). The mean AgNOR count of spindle and mononuclear cells were 4.7 in CGC lesions and 2.5 in peripheral lesionsConclusion: Evaluation of AgNORs showed that both MGC and fraction of mononuclear cells in CGCG were significantly higher than that in PGCG.Key words: Giant cell lesion, nucleolar organizer. (J Bagh Coll Dentistry 2008; 20(2):67-70) | ||
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