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Synthesis of Some Heterocyclic Compounds Containing Tetrahydroisoquinoline Moiety | ||
| Journal of Education and Science | ||
| Article 14, Volume 26, Issue 5, 2013, Pages 135-144 PDF (410.79 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2013.163063 | ||
| Authors | ||
| Mohammad Ahmad Al-Iraqi* ; Ahmad Waleed Najem* | ||
| Department of Chemistry, College of Science, University of Mosul | ||
| Abstract | ||
| ABSTRACT This research involves synthesis of some five membered heterocyclic compounds using 1,2,3,4-tetrahydroisoquinoline as a synthone. The initial step in this research involves the reaction of 1,2,3,4-tetrahydroisoquinoline with ethyl chloroacetate to form ethyl α-(1,2,3,4-tetrahydroisoquinolin-2-yl) acetate (1), which was converted to the hydrazide (2). This hydrazide was used to prepare some heterocyclic compounds, such as substituted oxadiazoles (7-10, 23) and thiadiazoles (11-14) via preparation of intermediate compounds such as diacylhydrazines (3-6), hydrazones (15-18) and substituted oxadiazoline compounds (19-22) and (24-27). The synthesized compounds were identified on the basis of some physical and IR spectral data. | ||
| Keywords | ||
| Tetrahydroisoquinoline; oxadiazole; thiadiazole; hydrazide; diacylhydrazine; heterocyclic compounds | ||
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