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Spectrophotometric determination of a number of aliphatic amines in aqueous solution and application to some pharmaceutical preparations | ||
| Journal of Education and Science | ||
| Article 27, Volume 26, Issue 5, 2013, Pages 17-32 PDF (799.35 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2013.163076 | ||
| Authors | ||
| Thabet Saeed Ghabsha* 1; Yousry Ibrahim Al-Nuaimi* 2 | ||
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Mosul | ||
| 2Physiology, Biochemistry and Medicines Branch, College of Veterinary Medicine, University of Mosul | ||
| Abstract | ||
| ABSTRACT A simple , rapid and sensitive spectrophotometric method for the determination of aliphatic amines was developed .The method is based on the proton transfer reaction using 3,5- dinitrosalicylic acid (DNS) reagent in basic medium forming colored products with maximum absorption at 415 nm .The molar absorptivity ranged from 5100 l. mol-1 .cm-1 for tributylamine to 12000 l. mol-1.cm-1 for dibutylamine .The method is obeyed Beer’s law over the concentration range (0.12-12) µg.ml-1.The accuracy ( average recovery ) is 99.73% and the precision (RSD) is less than 4.50% .This method is applied successfully for the assay of ethanolamine and ethylenediamine in their pharmaceutical preparations . | ||
| Keywords | ||
| 3,5- dinitrosalicylic acid (DNS); aliphatic amines; aqueous medium; spectrophotometry | ||
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