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Preparation of a number of heterocyclic compounds derived from benzotrazole | ||
| Journal of Education and Science | ||
| Article 37, Volume 26, Issue 5, 2013, Pages 156-172 PDF (698.36 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2013.163097 | ||
| Authors | ||
| Mohamed Khedr Mohamed* 1; Ahmed Khedr Ahmed* 2 | ||
| 1Northern Environmental Protection and Improvement Service, Kirkuk Environment Directorate, Kirkuk,Iraq | ||
| 2Chemistry Department, College of Education, Mosul University The Ministry of Environment | ||
| Abstract | ||
| ABSTRACT In this thesis, a number of heterocyclic compounds with five-memberd , such as substituted oxadiazole , thiadiazole , pyrazole , iso andoline-1,3-dione , also the preparation of pyrroline and pyrrolidine compounds . The ester compound (1) was synthesized from the reaction of benzotriazole with ethyl chloroacetate. The hydrazide (2) was prepared from the reaction of ester (1) with hydrazine hydrate , 1,3,4- Oxadiazole-5-thiol (3) was synthesized from the reaction of hydrazide (2) with carbon disulfide in potassium hydroxide , 2,5-disubstituted 1,3,4-oxadiazole (4) compounds was prepared by reaction of ester (1) with hydrazide (2) in presence phosphorus oxychloride , while treatment of the hydrazides with substituted benzoic acid (4-chloro and 2-nitro) in the presence of phosphorous oxachloride gave disubstituted 1,3,4-oxadiazole (5,6) , Pyrazolone (7) was synthesized from the reaction of hydrazide (2) with methyl acetoacetate , The pyrazole (8) was synthesized from the reaction of hydrazide (2) with acetyl acetone , 2-(benzotriazolyle acetamido) iso andoline-1,3-dione (9) compounds was prepared by reaction of hydrazide (2) with phthalic anhydride , pyrroline-2,5-dione (10) was prepared from the reaction of hydrazide (2) with malic anhydride , pyrrolidine-2,5-dione (11) was prepared from the reaction of hydrazide (2) with succinic anhydride , 2-Amino-1,3,4-thiadiazole (13) was prepared from the reaction of acid (12) with thiosemicarbazide in phosphorus oxychloride , Physical and available spectral were used to confirm structures . | ||
| Keywords | ||
| preparation; heterocyclic compounds; benzotrazole | ||
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