The role of vitamin C and E in improving hearing loss in patients with type 2 diabetes

Merkhan, Marwan M.; Abdullah, Kassim S.

doi:10.33899/mmed.2020.164162

	The role of vitamin C and E in improving hearing loss in patients with type 2 diabetes
Annals of the College of Medicine, Mosul
Article 13, Volume 41, Issue 2, 2019, Pages 184-189 PDF (416.87 K)
Document Type: Research Paper
DOI: 10.33899/mmed.2020.164162
Authors
Marwan M. Merkhan^* ¹; Kassim S. Abdullah²
¹Department of Pharmacology and Toxicology, College of pharmacy, University of Mosul, Iraq
²Department of Pharmacology, College of Medicine, University of Mosul, Iraq
Abstract
*Objective:* to evaluate the effect of antioxidant vitamins on hearing loss in diabetic patients. *Patients and methods:* Sixty type 2 diabetic patients with positive pure tone audiogram (PTA) enrolled in the study and divided into two groups: each group consists of thirty patients, group one was put on antioxidant therapy, and group two on placebo therapy, for 2 months duration. Thirty healthy individuals were kept as a control. Fasting blood sugar (FBS), and malondialdehyde (MDA) were measured in all groups. MDA and PTA were repeated after therapy. *Results:* The FBS and MDA are higher in diabetic patients, and beneficial effects of the administration of vitamin E and C combination on the oxidative stress and significant improvement, with mean differences of 12.5±7.79 decibel (dB), in the sensorineural hearing loss (SNHL) in diabetic patients were obtained. *Conclusion:* the present study demonstrated that diabetic patients have exaggerated oxidative stress, and administration of vitamin E and C combination had beneficial effect on the oxidative stress, and on the SNHL in diabetic patients with mean differences of 12.5±7.79 dB (p<0.001).
Keywords
diabetes; oxidative stress; hearing deficit; Antioxidants

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