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Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction. | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 13, Issue 3, 2018, Pages 23-36 PDF (0 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.32894/kujss.2018.13.3.3 | ||
| Author | ||
| Sunbul Mustafa Anwar* | ||
| Department of Chemistry, Collage of Science, University of Kirkuk, Kirkuk, Iraq. | ||
| Abstract | ||
| An easy and simple spectrophotometric method was described for estimating chlorpromazine Hydrochloride drug in aqueous solution. Where The method was adopted on oxidative coupling reaction of the drug with p- nitro aniline in the presence of ceric(IV) ammonium nitrate and hydrochloric acid solution an orange-brown product dye was obtainded with maximum absorption at 525 nm. with moler absorptivity of 9.24×103 l. mol-1. cm-1 and sandell's sensitivity of 0.0385 µg.cm-2 Beer's law is obeyed over the concentration range of (12-46) µg.ml-1. The method was applied successfully for the estimating the drug it's on pure condition or in pharmaceutical preparations (Largactil drug).). | ||
| Keywords | ||
| chlorpromazine hydrochloride; Oxidative Coupling; Spectrophotometric | ||
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