Estimation of the Leptin Hormone and Some Biochemical Variables in Patients with Lung Cancer in Kirkuk Province

AL-Qarghuli, Seraj A.; Laylani, Layla A.; Khalil, Arkan A.

doi:10.32894/kujss.2019.14.2.5

	Estimation of the Leptin Hormone and Some Biochemical Variables in Patients with Lung Cancer in Kirkuk Province
Kirkuk Journal of Science
Article 1, Volume 14, Issue 2, 2019, Pages 72-82 PDF (541.28 K)
Document Type: Research Paper
DOI: 10.32894/kujss.2019.14.2.5
Authors
Seraj A. AL-Qarghuli^* ¹; Layla A. Laylani²; Arkan A. Khalil³
¹Department of Biology, College of science, Tikrit university, Tikrit, Iraq.
²Kirkuk Technical Institute, Northern Technical University, Kirkuk, Iraq.
³Kirkuk health directorate, Kirkuk, Iraq.
Abstract
This study aimed to estimate the level of leptin hormone and some biochemical variables in patients with lung cancer. Twenty five patients with lung cancer and 24 healthy control were enrolled in this study. The results showed a significant decrease in the level of leptin in patients with lung cancer compared to healthy control. In group of patients with lung cancer who had BMI ( 20 – 23 kg/m2 ), ( 24–26 kg/m2 ), ( more than 30 kg/m2 ) the levels of leptin were (1.42 ± 0.54), (4.35 ± 2.19), (8.75 ± 1.2) ng/ml respectively, comparing with the healthy control (4.89 ± 1.29), (6.85 ± 1.49), (9.85 ± 2.62) ng/ml respectively. The results also showed that there was a significant increase in activity of ALT in patients group (30.8 ± 16.4) U/L compared to healthy control (22.8 ± 6.55), while there was no statistically significant differences in the activity of AST in patients group (25.4 ± 8.9) U/L compared to healthy control (27 ± 9.2). There were no statistically significant correlation between leptin level with ALT ( r = -0.104 ) and AST ( r = 0.092 ). AST ( r = 0.092).
Keywords
Lung Cancer; Leptin; Body mass index BMI

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