Mohammed, I., Kakey, I., Farimani, M. (2020). Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats. , 34(1), 109-113. doi: 10.33899/ijvs.2019.125557.1076
Ismael H. Mohammed; Ismail S. Kakey; Mahdi M. Farimani. "Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats". , 34, 1, 2020, 109-113. doi: 10.33899/ijvs.2019.125557.1076
Mohammed, I., Kakey, I., Farimani, M. (2020). 'Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats', , 34(1), pp. 109-113. doi: 10.33899/ijvs.2019.125557.1076
Mohammed, I., Kakey, I., Farimani, M. Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats. , 2020; 34(1): 109-113. doi: 10.33899/ijvs.2019.125557.1076

Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats

Iraqi Journal of Veterinary Sciences
Article 17, Volume 34, Issue 1, 2020, Pages 109-113    PDF (290.93 K)
Document Type: Research Paper
DOI: 10.33899/ijvs.2019.125557.1076
Authors
Ismael H. Mohammed* 1; Ismail S. Kakey2; Mahdi M. Farimani3
1Department of Medical Microbiology, Faculty of Science and Health, Koya University, Koya, Iraq
2Department of Biology, Faculty of Science and Health, Koya University, Koya, Iraq
3Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran
Abstract
Prosopis farctais belonged to Mimosaceae family, commonly known as mesquite. It was chosen to investigate their effect on α-glucosidase inhibitory activity (in-vitro), serum glucose and liver functions. Roots, fruits, and leaves of P. farcta, were extracted by n-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC50 was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of P. farcta showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with P. farcta extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of P. farcta showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of P. farcta showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the P. farcta extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions.
Keywords
<i>Prosopis farcta</i>; diabetes; Rats
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