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Synthesis of Some New Benzoxazepine Compounds Form Derivatives of Schiff Bases | ||
| Journal of Education and Science | ||
| Article 16, Volume 29, Issue 1, 2020, Pages 218-232 PDF (1.44 M) | ||
| DOI: 10.33899/edusj.2020.164374 | ||
| Authors | ||
| Amena A. Ahmed; Ahmad Kh. Ahmad; Natiq G. Ahmed | ||
| Abstract | ||
| This study involved synthesize (1,3) oxazepine. The step 1 includes the preparation of compound (1), (5-Bromo-2-mercapto-6-(4-methoxyphenyl) pyrimidin-4(3H)-one), by the condensation of anisaldehyde and ethylbromoacetat and thiourea in EtOH. In the step2, chalcones (2-6) have been produced. The reaction of compound (1) with chalcones (2-6) that gives azo Michael adduct (7-11) is made in the third step. Schiff’s bases (12-16) were prepared by the reaction ketones (7-11) with 2,4-dinitroaniline. Finally preparation of new benzo [1,3] oxazepine compounds (17-21) are prepared by the reaction of phthalic anhydride with Schiff’s bases. The synthesized compounds are identified by physical (melting points, colour change) and spectral methods such as (IR, proton-nmr). | ||
| Keywords | ||
| β-amino ketones; Michael addition; oxazepine | ||
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