Synthesis of New Oxazepine and Thaizolidine Compounds derived from Pyrimidine-2(2H)-one

Sulyman, Zainab Hassan; Ahmed, Natiq Ghaniem

doi:10.33899/edusj.2019.125908.1004

	Synthesis of New Oxazepine and Thaizolidine Compounds derived from Pyrimidine-2(2H)-one
Journal of Education and Science
Article 13, Volume 29, Issue 2, 2020, Pages 186-200 PDF (793.59 K)
Document Type: Research Paper
DOI: 10.33899/edusj.2019.125908.1004
Authors
zainab hassan sulyman^* ; natiq ghaniem ahmed
Department of chemistry, college of Education of pure science, Mosul university ,Mosul, Iraq
Abstract
In this paper the compounds (11-20) (methyl pyrimidine - 2(1H)-one and others phenyl pyrimidine -2(1H)- one) that will prepared from α, β unsaturated carbonyl compounds they are called chalcones, that compounds prepared from reaction of different aldehyde (4-methoxy benzaldehyde, 2-nitro benzaldehyde, 3-nitrobenzaldehyde, 4-N,N—dimethyle amino benzaldehyde, benzaldehyde, 4-nitro-benzaldehyde) with different ketones (acetone, acetophenone, 2-nitro acetophenone, 3-nitro acetophenone) after prepared this compounds and purified it and mesurment for physical, chemical and spectroscopy that we can do to get chalcones that reacted with urea under known chemical conditions to get pyrimidinone compounds we needed. pyrimidine compounds were reacted with two aromatic amines (2,4-dinitro aniline and 4- amino acetophenone) using glacial acetic acid as catalyst in absolute ethanol giving a new compounds of schiff's bases (21-40). New thiazolidine 4-one (41-50) were synthesized from reactions of Schiff's bases (21-30) with thioglycolic acid in absolute ethanol. 1,3- oxazepine derivatives. (51-60) are prepared from reaction between Schiff's bases (31-40) with malic anhydrid in absolut ethanol. The structures of the Synthesized compounds were estimated by IR, 1H- NMR and some physical data.
Keywords
pyrimidine,,; ,،,؛Schiff's bases,,; ,،,؛Thiazolidine,,; ,،,؛1,,; ,،,؛3- oxazepine

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