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A Friendly Environment Approach for determination of paracetamol | ||
| Journal of Education and Science | ||
| Article 16, Volume 29, Issue 2, 2020, Pages 230-240 PDF (494.67 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2019.125964.1011 | ||
| Author | ||
| Hanaa Mahmood* | ||
| Dept.Chemistry, Coll.Science, Univ.Mosul | ||
| Abstract | ||
| Abstract This paper involves a determination of paracetamol using less environment harmful reagent; the hydroxy analog of the pharmaceutical naproxen replaced a chemical reagent in which it is used as a coupling agent for the diazotized p-aminophenol (the hydrolysis product of paracetamol), the paper offers a determination of an analgesic paracetamol in the presence of high content of another analgesic. Paracetamol azo-dye exhibits maximum absorption at 500 nm. Beer's law is obeyed over the concentration range from 10 to 650 µg/20ml, (i.e. 0.5-32.5 ppm) with a good sensitivity (molar absorptivity 1.2x104 l.mol-1.cm-1), good precision (RSD better than ±0.275%) and high accuracy (relative error less than + 0.77%), Sandell's sensitivity index is 0.0124µg.cm-2, the limit of detection (LOD) is 0.0030 µg/ml and the limit of quantitation (LOQ) is 0.0101 µg/ml. The method has been successfully applied for determination for paracetamol in dosage forms and its already applicable for the determination of paracetamol in presence of naproxen. | ||
| Keywords | ||
| Key words: paracetamol,,; ,،,؛naproxene,,; ,،,؛spectrophotomety,,; ,،,؛friendly environment | ||
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