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Spectrophotometric Assay of Piperazine hexahydrate in Pharmaceutical Formulation with 3,5- Dinitrosalysilic Acid Reagent | ||
| Journal of Education and Science | ||
| Article 4, Volume 29, Issue 3, 2020, Pages 46-57 PDF (535.36 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2020.126231.1023 | ||
| Authors | ||
| Usra Ibrahim Al-Neaimy1; USRA Ibrahim Al-Neaimy* 2 | ||
| 1Veterinary Medicine Collage - Mosul University - mosul - Iraq | ||
| 2Physiology, Biochemistry and Pharmacology Department / College of Veterinary Medicine / University of Mosul ,Mosul,Iraq | ||
| Abstract | ||
| A simple spectrophotometric method for the determination of piperazine hexa- hydrate was developed. The method was based on the proton transfer reaction with 3,5- dinitrosalicylic acid (DNS) in basic solution to form yellow product showing a maximum absorbance at 410 nm with molar absorptivity of 8350 l/mol.cm . The method is obeyed Beer’s law over the concentration range 0.5-20 µg/ml. The average recovery % of the method is 99.12% and RSD % of the method is less than 2%. The method was applied for the determination of piperazine hexahydrate in pharmaceutical formulation as elixir and the results were in good agreement with the standard addition method .- - - - - - - - - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - | ||
| Keywords | ||
| determination,,; ,،,؛piperazine,,; ,،,؛pharmaceutical formulation | ||
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