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Spectrophotometric Determination of Mefenamic Acid Using The Oxidation Reduction Reaction of Iodide and Iodate Ions | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 34, 2014, Pages 363-374 | ||
| Authors | ||
| Lena Samir Awadees; Nabeel Sabeh Othman | ||
| Abstract | ||
| Abstract A sensitive indirect spectrophotometric method is proposed for determining mefenamic acid in pure form and in its pharmaceutical preparations. The method is based on the reaction of mefenamic acid with potassium iodate and potassium iodide to liberate iodine , which is immediately converted to triiodid ion complex in presence of an excess of potassium iodide solution to form yellow dye ,which exhibits maximum absorption at 347 nm. Beer’s law is obeyed over the range 10 to g of mefenamic acid in final volume 25 ml, i.e.,0.4- 48 ppm with a molar absorptivity of 0.904×104l. mol-1.cm-1 and Sandell’s sensitivity index of g.cm-2, a relative error of -0.625 to 1.470 % and a relative standard deviation of ±0.336 to ±1.764 % depending on the concentration level . The proposed method has been applied successfully to determine mefenamic acid in pharmaceutical preparations. | ||
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