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The Antimicrobial Activity (Antibacterial, Antifungual) Of Some New 3-Substituted Isobenzofuran-1(3H)-One Derivatives | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 34, 2014, Pages 303-308 | ||
| Authors | ||
| Mahmoud J. Abussaud; Ahmed O. Maslat; ; a J. Mahrath | ||
| Abstract | ||
| Abstract In this research a new series of 3-(substituted) isobenzohuran-1(3H)-one(B,D) and O-benzoyl benzamide derivatives (C,E) were studied successfully . The synthesis of these compounds has been described in the scheme 1. These products were screened for antifungal, antibacterial and enotoxic effect. It was found that all tested compounds have antifungal activity. Compound A1,A2,B2 and C3 were found to be active against Escherichia coli ,Bacillus subtilis and Staphylococcus aureus .Genotoxic effects using Ames test showed chart compound A1 and A2 have a weak base-pair substitution mutagenicity while a clear base- pair substitution mutagenic activity was shown by B4. Using TA100-strain of salmonella typhimurium compound D showed a framshift mutagenicity while a weak oxidative mutagenic action was revealed by compound E no change on the mutagenicty of the tested chemicals was observed after using the S9 metabolic action system. | ||
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