The Value of Free Thyroid Hormones and Aspartate Aminotransferase in Vaginal Washing Fluid for Detection of Preterm Pre-Labor Rupture of Membrane

, Maha Mohamed Jasim Al-Bayati; , Athmar Maamon Salman; , Eaman Marouf Muhammad

	The Value of Free Thyroid Hormones and Aspartate Aminotransferase in Vaginal Washing Fluid for Detection of Preterm Pre-Labor Rupture of Membrane
Iraqi Postgraduate Medical Journal
Article 1, Volume 18, Issue 1, 2019, Pages 52-58 PDF (0 K)
Authors
Maha Mohamed Jasim Al-Bayati; Athmar Maamon Salman; Eaman Marouf Muhammad
Abstract
ABSTRACT: BACKGROUND: Preterm pre-labor rupture of membrane occurs in about 2% of all pregnancies. The most frequent consequences of preterm pre-labor rupture of membrane is preterm delivery, sepsis and pulmonary hypoplasia. The correct diagnosis of preterm pre-labor rupture of membrane is crucial and successful management will be based upon it. OBJECTIVE: To determine whether measurement of vaginal washing fluid aspartate aminotransferase(AST) , free triiodothyronine (free T3) and thyroxin(free T4) were useful tests for the diagnosis of preterm pre-labor rupture of membrane. STUDY DESIGN: A case - control study. SETTING: :This study was conducted at department of Obstetrics and Gynecology of AL-Yarmouk teaching Hospital and National center for Diabetes PATIENTS, MATERIALS AND METHODS: It included hundred pregnant women with a gestational age ranging between 24 - 36+6 weeks. They were divided into two groups, the study group which included fifty pregnant women presented with preterm pre-labor rupture of membrane and the control group which includes fifty pregnant women without any complaint, matched for gestational age. All women underwent sterile speculum vaginal examination. Free triiodothyronine and free thyroxin levels were measured by using Enzyme immune assay method, and aspartate aminotransferase level was measured by using colorimetric method, in vaginal washing fluid. RESULTS: Vaginal washing fluid free T3, free T4 and AST levels were significantly higher in the study group (1.15), (0.071), (4.9) respectively compared with the control group (0.93), (0.048), (4.5) respectively. Vaginal washing fluid free T4 having the largest area under the curve on receiver operating characteristic curve (ROC) analysis (P<0.001). ROC curve analysis showed that free T3 validity results in predicting preterm pre labor rupture of membrane among pregnant women were (cut-off 1.07pg/ml, sensitivity 88%, specificity 76% and accuracy 82%), free T4 validity results were (cutoff 0.055pg/ml, sensitivity 84%, specificity 80% and accuracy 82%) and AST validity results were (cut-off 4.9IU/L, sensitivity 52%, specificity 80% and accuracy 66%). CONCLUSION: Measurement of aspartate aminotransferase free triiodothyronine , and thyroxin in vaginal washing fluid of suspected and diagnosed patient presented with preterm pre labor rupture of membrane found to be a useful markers for the diagnosis of preterm pre labor rupture of membrane. .
Keywords
KEYWORDS; aspartate aminotransferase; pre; labor rupture of membrane

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