Ki-67 Expression in Breast Cancer, Its Correlation with ER, PR and Other Prognostic Factors in Nineveh Province

Al-Nuaimi, Hatem Abd-AlMajeed; Hamdi, Elaf; Mohammed, Banan Burhan

doi:10.33899/mmed.2020.127375.1037

	Ki-67 Expression in Breast Cancer, Its Correlation with ER, PR and Other Prognostic Factors in Nineveh Province
Annals of the College of Medicine, Mosul
Article 1, Volume 42, Issue 1, 2020, Pages 1-10 PDF (993.08 K)
Document Type: Research Paper
DOI: 10.33899/mmed.2020.127375.1037
Authors
Hatem Abd-AlMajeed Al-Nuaimi¹; Elaf Hamdi^* ²; Banan Burhan Mohammed³
¹Unit of Histopathological Examination, Laboratory of Al-Jumhuri Teaching Hospital, Nineveh
²Pathology, Medical College, University Of Mosul, Mosul, Iraq
³Department of Pathology, College of Medicine, University of Mosul, Nineveh Province, Iraq
Abstract
Objectives: The aggressiveness of malignant tumors of breast can be correlated with the proliferation of neoplastic cells, and this detected by immunohistochemical study of proliferative index (Ki-67). American Society of Clinical Oncology (ASCO) does not recommend the use of Ki-67 routinely to predict the outcome of breast cancers, therefore the aim of current study is to detect the expression of Ki-67 in patients with primary breast cancer in Nineveh Province/North of Iraq and to correlate it with estrogen and progesterone receptors in addition to other prognostic factors. Methods: In this retrospective-case series study eighty cases of histologically proven primary breast carcinomas were included. The cases were collected from hospitals and private laboratories in Nineveh Province / North of Iraq and studied Immunohistochemicaly for Ki-67, estrogen receptor (ER) and progesterone receptor (PR) were done on tissue sections embedded in paraffin wax. An area with the maximum proliferation was chosen to evaluate Ki-67 and the cases with ≥20% positive nuclei were considered as high Ki-67 expression while those with <20% positive nuclei were considered as low Ki-67 expression.(10-14). The findings of Ki-67 were correlated with the age of the patients, histological type, grade of the tumors and with the estrogen and progesterone receptors. Results: The Ki-67 immunoreactivity was highly expressed in (45%) of the cases. Estrogen and progesterone receptors observed in (77.5%) and (67.5%) of the cases respectively. The Ki-67 was significantly associated with grade of tumor, estrogen receptor and progesterone receptor (P= 0.0057, 0.037 and 0.006 respectively). While the association with patientsˈage and histological types were not statistically significant. Conclusion: Ki-67 expression shows a significant direct correlation with grade of tumors and a significant inverse correlation has been shown with a well-known predictive factors, (estrogen and progesterone receptors).
Keywords
breast cancer,,; ,،,؛immunohistochemistry,,; ,،,؛Ki-67,,; ,،,؛estrogen receptor and progesterone receptor

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