Effectiveness of antiplatelet thromboprophylaxis in myeloma patients using immunomodulators in Kurdistan region-Iraq

Botany, Rezhen; K. Yassin, Ahmed; Hiwaizi, Firiad; Hassan, Abid M.; Getta, Hisham A.; Khoshnaw, Najmaddin Salih Husen; Jalal, Sana D.; Mohammed, Akram M.; Hasan, Kawa M.; Abdulla, Dana A.; Badi, Ameer I.A.; Al-Allawi, Nassir A. S.; Safar, Banaz M.; Abdulla, Basil K.; Shamoon, Rawand P.; Amin, Truska A.; Mohamed, Zeki A.; Mohammed, Ali I.; Hussein, Diveen J.; Mohammed, Nawsherwan S.

doi:10.33899/mmed.2020.126833.1023

	Effectiveness of antiplatelet thromboprophylaxis in myeloma patients using immunomodulators in Kurdistan region-Iraq
Annals of the College of Medicine, Mosul
Article 5, Volume 42, Issue 1, 2020, Pages 35-41 PDF (971.86 K)
Document Type: Research Paper
DOI: 10.33899/mmed.2020.126833.1023
Authors
Rezhen Botany^* ¹; Ahmed K. Yassin²; Firiad Hiwaizi³; Abid M. Hassan⁴; Hisham A. Getta⁴; Najmaddin Salih Husen Khoshnaw⁵; Sana D. Jalal⁶; Akram M. Mohammed⁷; Kawa M. Hasan⁸; Dana A. Abdulla⁶; Ameer I.A. Badi⁹; Nassir A. S. Al-Allawi⁹; Banaz M. Safar⁷; Basil K. Abdulla⁷; Rawand P. Shamoon¹⁰; Truska A. Amin¹¹; Zeki A. Mohamed⁴; Ali I. Mohammed⁶; Diveen J. Hussein¹²; Nawsherwan S. Mohammed⁸
¹Clinical Haematology nanakali hospital
²Department of medicine, college of medicine, Hawler medical university, Kurdistan region, Iraq
³nanakali hospital for blood disease and cancer
⁴Department of Hematology, Azadi Teaching Hospital, Duhok. Kurdistan region, Iraq
⁵Department of Pathology, College of Medicine, University of Sulaymaniyah, Kurdistan region, Iraq,
⁶Department of Pathology, College of Medicine, University of Sulaymaniyah, Kurdistan region, Iraq
⁷Department of Hematology, Hewa Cancer Hospital, Sulaymaniyah, Ministory of Health, Kurdistan region, Iraq
⁸Department of of Medicine, College of Medicine, Hawler Medical University, Kurdistan region, Iraq
⁹Department of Hematology, College of Medicine, University of Duhok, Duhok, Kurdistan region, Iraq
¹⁰Ministry of Higher Education, Kurdistan region, Iraq
¹¹Ministry of HigDepartment of Hematology, Hewa Cancer Hospital, Sulaymaniyah, Ministory of Health, Kurdistan region, Iraqher Education, Kurdistan region, Iraq
¹²Department of Hematology, Nanakali Hospital, Erbil, Kurdistan region, Iraq
Abstract
Abstract: Objective: To evaluate the effectiveness of antiplatelet drugs in preventing thrombosis in multiple myeloma patients treated by immunomodulatory drugs Methods: The study includes a hundred seventy six patients of symptomatic multiple myeloma treated in hematology unit of three centers in Kurdistan region of Iraq from February 2014 to July 2019. Demographic data were obtained from patient’s file, including the type of immunomodulatory drugs, antiplatelet use, thrombotic events and their site, presence of other comorbidity, and whether the thrombosis was before or after the diagnosis of multiple myeloma. Background and objectives: Multiple myeloma is a malignant disease that affect both gender and associated with increased risk of thrombosis, one of the effective method of treating myeloma is through using immunomodulatory drugs especially when combined with high dose dexamethasone with in turn boost the risk of thrombosis, in this study we investigate the effect of antiplatelet in preventing thrombosis. Methods: This is a retrospective study that include 176 cases that are collected from cancer centers at Kurdistan region of Iraq from Feb/2014 to Jul/2019 information gathered through questionnaire. Results: Regardless the type of therapy in the study sample 11.1% who were taking anti-platelet therapy developed thrombotic attack compared with 46.9% who were not taking the anti-platelets therapy. The incidence of the thrombotic attack among those myeloma patients who used immunomodulatory drugs was 9.6% who were on anti-platelet drugs which is significantly lower than the rate (52%) among patients not taking the anti-platelet drugs. Conclusions: As multiple myeloma is a malignant disease and treatment with immunomodulatory drugs associated with increased risk of thrombosis, antiplatelet drug is an effective measure when used as a prophylaxis for preventing thrombosis. Keywords: Multiple myeloma, Thrombosis, Antiplatelet
Keywords
Keywords: Multiple myeloma; Thrombosis; Antiplatelet

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