- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Review study of the role of genetically modified Lactococcus lactis in prevention of type-1 diabetes mellitus | ||
| Annals of the College of Medicine, Mosul | ||
| Article 12, Volume 42, Issue 1, 2020, Pages 82-89 PDF (514.72 K) | ||
| Document Type: Review Paper | ||
| DOI: 10.33899/mmed.2020.127468.1040 | ||
| Authors | ||
| Abeer Mudhafar Al-Humaidhi* 1; Ahmed Abdulkareem Shegaya2; Ali Qusay Sagban2; Hussain Ali Jaleel2; Karrar Mahtar Ateha2; Maitham Jaber Abdulhussain2 | ||
| 1Department of Pharmacology and toxicology-College of Pharmacy-University of Thi-Qar | ||
| 2Fifth stage students, College of Pharmacy, University of Thi-Qar, Iraq | ||
| Abstract | ||
| Globally, type 1 diabetes mellitus is a common chronic autoimmune disease impacts a great number of individuals. It results from devastation of insulin-secreting beta cells of the pancreas described by incompetence to secrete insulin resulting in hyperglycemia that need a ceaseless treatment with insulin. Further, complications of type 1 diabetes can influence numerous organs and may prompt premature death. Therefore, the requirement to find new strategies for managing type 1 diabetes other than exogenous insulin administration got obligatory. Curiously, genetically modified Lactococcus lactis can incite immunological tolerance; downregulate mechanisms linked to adaptive immunity; and reduce disease-related inflammation, while leaving the remainder of the immune system flawless. This review aimed to overview genetically modified Lactococcus lactis, it's expressing proteins, pathogenesis of type 1diabetes, and therapeutic effects of genetically modified Lactococcus lactis in animal model of type 1daibetes, further, to display the possible mechanisms through which the genetically modified Lactococcus lactis can act. It has been presumed that targeting antigen-specific pathway utilizing genetically modified Lactococcus lactis has potential therapeutic impacts in experimental animals with type 1 diabetes mellitus. This could open up new and safe therapeutic prospects in autoimmune disease domain such as type 1diabetes mellitus. | ||
| Keywords | ||
| antigen specific therapy,,; ,،,؛bioactive proteins,,; ,،,؛immune tolerance,,; ,،,؛Lactococcus lactis,,; ,،,؛type-1 diabetes | ||
|
Statistics Article View: 307 PDF Download: 355 |
||