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Using of Diazotized 2,4-Dinitroaniline in Spectrophotometric Estimation of Phenylephrine Hydrochloride | ||
| Rafidain Journal of Science | ||
| Article 4, Volume 29, Issue 3, 2020, Pages 37-46 PDF (739.58 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rjs.2020.166310 | ||
| Authors | ||
| Shlear H. Hasan* 1; Nabeel S. Othman2; Kafia M. Surchi3 | ||
| 1Department of Food Technology/ College of Agriculture/ University of Salahaddin/ Erbil/ Iraq | ||
| 2Department of Chemistry/ College of Science/ Mosul University | ||
| 3Department of Chemistry/ College of Science/ University of Salahaddin/ Erbil/ Iraq | ||
| Abstract | ||
| The suggested work included simple accurate diazo-coupling spectrophotometric method for the determination of phenylephrine-HCl (PHEPH) in pure drug and tablet formulation. The method was based on coupling of PHEPH with diazotized 2,4-dinitroaniline in alkaline medium. The sensitivity expressed by the value of molar absorptivity of yellowish-orange azo- dye was 1.915 ×104 L. mol-1. cm-1, the maximum absorption at 455 nm and Beer's law obeyed within the range of 10-200 μg/10ml of PHEPH. The color of the product was highly stable and did not show a significant change in absorbance up to 60 min. with a recovery of 99.97% and a RSD% is 0.024%. The PHEPH in nose drop and syrup has been estimated with satisfactory results. | ||
| Keywords | ||
| 2; 4-dinitroaniline; Phenylephrine; Hcl; diazo-coupling; Spectrophotometric; pharmaceutical preparations | ||
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