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Immunohistochemical Expression of Actin and S100 in Pleomorphic Adenoma and Mucoepidermoid Carcinoma | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 2, 2011, Pages 51-55 | ||
| Authors | ||
| Ahlam H. Majeed; Farah S. Rasheed | ||
| Abstract | ||
| ABSTRACTBackground: Tumors of the salivary glands constitute an important area in the field of oral and maxillofacialpathology. These tumors have a special status in human neoplasia and probably the most complex histopathologicfeatures of the body organs and being heterogeneous. Pleomorphic adenoma (PA) is the most common benign;and mucoepidermoid carcinoma(MEC) is the most common malignant salivary gland tumors. Many investigationshave showed that myoepithelial cells play a major role in the histogenesis of PA and may be important in manyMECs. The aims of the study are to determine the presence and distribution of myoepithelial cell relatedimmunomarkers Actin and S100 in PA and MEC and to explore the histogenesis of these tumors in relation to theabove mentioned markers.Materials and methods: Seventeen formalin fixed paraffin embedded tissue blocks of PA, and other fifteen tissueblocks of MEC were included in the study. Diagnostic confirmation was performed through examination ofhematoxylin and eosin sections. Both tumors were immunohistochemically analyzed for the presence of actin andS100 protein.Results: There was a positive immunoreactivity for the expression of actin in PA (100%) with different score values,while for MEC, actin was negatively expressed in all of the cases (except in one case). There was a highly statisticalsignificant difference in the actin immunoexpression between the two tumors (p=0.000).There was a positive immunoreactivity for S100 protein expression in all of the cases of PA and MEC (100%) withdifferent score values; however, there was no statistically significant difference in the S100 immunoexpressionbetween them (p=0.545).Conclusion: The myoepithelial cells are associated with the histogenesis of salivary PA, and the negative expressionof actin in squamous, intermediate and mucous cells of MEC can be explained by the non-involvement of themyoepithelial cells in the histogenesis of this tumor.Key words: Pleomorphic Adenoma, Mucoepidermoid Carcinoma, Actin, S100. (J Bagh Coll Dentistry 2011;23(51-55). | ||
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